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1. Anesthesia-deep stages

2. Anoxia, cerebral hypoperfusion

3. B₆/Pyridoxal-phosphate dependencies

4. Drug overdose (e.g., phenobarbital)

5. Molybdenum cofactor deficiency

6. Nonketotic hyperglycinemia

7. Organic acidemias (neonatal encephalopathy-propionic academia)

8. Purine metabolism defects