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Baclofen
Musculoskeletal relaxant
< 2 years: 10-20 mg/day div. Q8 hr ; titrate dose every 3 days in increments of 5-15 mg/day to a maximum of 40 mg daily.
2 - 7 years: 20-30 mg/day div. Q8 hr ; titrate dose every 3 days in increments of 5-15 mg/day to a maximum of 60 mg daily.
≥ 8 years: 30-40 mg/day div. Q8 hr ; titrate dosage as above to a maximum of 120 mg daily.
Alternatively: start at 0.3 mg/kg/day div. Q8 hr and increase every 1-2 week(s) until reaching maintenance dose of: 0.75-2mg/kg/day
For > 10 years of age you can reach up to 2.5mg/kg/day
Adults: 5 mg three times daily; may increase by 5 mg/dose every 3 days to a maximum of 80 mg/day. 30 - 75mg) /day is considered the standard dosage range (24, 25).
PO
Cardiovascular: Hypotension (0% to 9% )
Gastrointestinal: Constipation
Musculoskeletal: Poor muscle tone
Neurologic: Asthenia (0.7% to 15% ), Dizziness Headache, Somnolence
Other: Fatigue (2% to 4% ), Shivering (0.5% to 1.3% )4
24. Simmonds HA, Cameron JS, Morris GS, Davies PM. Allopurinol in renal failure and the tumour lysis syndrome. Clin Chim Acta 1986;160(2):189-95 doi: 0009-8981(86)90141-5 [pii][published Online First: Epub Date]|.
25. Becker MA. Phosphoribosylpyrophosphate Synthetase Superactivity. 1993 doi: NBK1973 [bookaccession][published Online First: Epub Date]|.
