We provide you with the best medicine purchasing service

Quickly morph client-centric results through performance based applications. Proactively facilitate professional human capital for cutting-edge.

Download Now

img

Biotin

- Co-factor for carboxylases

- Biotinidase deficiency

- Biotin Responsive Basal Ganglia disease (BRBGD)

- Multiple carboxylase deficiency
Biotinidase deficiency, co-factor for carboxylases and Multiple carboxylase deficiency: 5-20 mg/day (8, 9, 30, 31).
BRBGD: 5-10 mg/kg/day (32-34).

10, 50 mg tablets / capsules

1 mg capsule

IV (available as part of a multivitamin complex)

PO

Administration of anticonvulsant medications may impair Biotin absorption, gastrointestinal upset.

4

8. Centre for Evidence-Based Medicine. Secondary Centre for Evidence-Based Medicine  2009. http://www.cebm.net/index.aspx?o=1025.

9. Loche S, Carta D, Muntoni AC, Corda R, Pintor C. Oral administration of arginine enhances the growth hormone response to growth hormone releasing hormone in short children. Acta Paediatr 1993;82(10):883-4

30. Batshaw ML, MacArthur RB, Tuchman M. Alternative pathway therapy for urea cycle disorders: twenty years later. J Pediatr 2001;138(1 Suppl):S46-54; discussion S54-5 doi: a111836 [pii][published Online First: Epub Date]|.

31. Di Minno G, Davi G, Margaglione M, et al. Abnormally high thromboxane biosynthesis in homozygous homocystinuria. Evidence for platelet involvement and probucol-sensitive mechanism. J Clin Invest 1993;92(3):1400-6 doi: 10.1172/JCI116715[published Online First: Epub Date]|.

32. Smolin LA, Benevenga NJ, Berlow S. The use of betaine for the treatment of homocystinuria. J Pediatr 1981;99(3):467-72

33. Wilcken DE, Wilcken B, Dudman NP, Tyrrell PA. Homocystinuria--the effects of betaine in the treatment of patients not responsive to pyridoxine. N Engl J Med 1983;309(8):448-53 doi: 10.1056/NEJM198308253090802[published Online First: Epub Date]|.

34. Wilcken DE, Dudman NP, Tyrrell PA. Homocystinuria due to cystathionine beta-synthase deficiency--the effects of betaine treatment in pyridoxine-responsive patients. Metabolism 1985;34(12):1115-21

footer shape