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Cholestyramine

Familial Hypercholesterolemia

Children ≤10 years: Initial: 2 g/day; titrate dose based on efficacy and tolerance; range: 1- 4 g/day.

Children >10 years and Adolescents: Initial: 2 g/day; titrate dose based on efficacy and tolerance, up to 8 g/day.

Adults: 3 - 4 grams, three to four times/day to maximum of 16-32 grams in 2-4 divided doses (42-45).

4 g resin in packets

PO

Abdominal discomfort, constipation, flatulence, nausea and vomiting.

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42. Clayton PT. Disorders of bile acid synthesis. J Inherit Metab Dis 2011;34(3):593-604 doi: 10.1007/s10545-010-9259-3[published Online First: Epub Date]|.

43. Clayton PT. Inborn errors of bile acid metabolism. J Inherit Metab Dis 1991;14(4):478-96

44. Berginer VM, Salen G, Shefer S. Long-term treatment of cerebrotendinous xanthomatosis with chenodeoxycholic acid. N Engl J Med 1984;311(26):1649-52 doi: 10.1056/NEJM198412273112601[published Online First: Epub Date]|.

45. Elias ER, Irons MB, Hurley AD, Tint GS, Salen G. Clinical effects of cholesterol supplementation in six patients with the Smith-Lemli-Opitz syndrome (SLOS). American journal of medical genetics 1997;68(3):305-10

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