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Hydroxocobalamin (vitamin B12)

Disorders of cobalamin metabolism

1mg IM daily or  Oral dose: 10 mg once or twice daily (8, 9, 84-86).
1000 mcg/mL injection for solution
Tablets

IM or PO

Increase blood pressure,  Erythema, nausea, decrease lymphocyte count,  Headache, red color urine.

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8. Centre for Evidence-Based Medicine. Secondary Centre for Evidence-Based Medicine  2009. http://www.cebm.net/index.aspx?o=1025.

9. Loche S, Carta D, Muntoni AC, Corda R, Pintor C. Oral administration of arginine enhances the growth hormone response to growth hormone releasing hormone in short children. Acta Paediatr 1993;82(10):883-4

84. Robins SJ, Collins D, Wittes JT, et al. Relation of gemfibrozil treatment and lipid levels with major coronary events: VA-HIT: a randomized controlled trial. JAMA 2001;285(12):1585-91 doi: joc01957 [pii][published Online First: Epub Date]|.

85. Smalley CM, Goldberg SJ. A pilot study in the efficacy and safety of gemfibrozil in a pediatric population. J Clin Lipidol 2008;2(2):106-11 doi: S1933-2874(08)00070-6 [pii]

10.1016/j.jacl.2008.02.003[published Online First: Epub Date]|.

86. Calderwood S, Kilpatrick L, Douglas SD, et al. Recombinant human granulocyte colony-stimulating factor therapy for patients with neutropenia and/or neutrophil dysfunction secondary to glycogen storage disease type 1b. Blood 2001;97(2):376-82

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