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Ketamine

NKH

1 mg/kg/day in 4 divided doses. Titrate it up to 30 mg/kg/day according to clinical and biochemical response (94-97).

10 mg/mL,50 mg/mL, and 100 mg/mL solution for  injection (maybe be used orally after mixing the dose with 0.2 – 0.3 mL/kg of cola or other beverages.

Oral or IV or IM

Hypertension, tachycardia.

4

94. Muenzer J, Gucsavas-Calikoglu M, McCandless SE, Schuetz TJ, Kimura A. A phase I/II clinical trial of enzyme replacement therapy in mucopolysaccharidosis II (Hunter syndrome). Mol Genet Metab 2007;90(3):329-37 doi: 10.1016/j.ymgme.2006.09.001[published Online First: Epub Date]|.

95. Muenzer J, Wraith JE, Beck M, et al. A phase II/III clinical study of enzyme replacement therapy with idursulfase in mucopolysaccharidosis II (Hunter syndrome). Genet Med 2006;8(8):465-73 doi: 10.1097/01.gim.0000232477.37660.fb[published Online First: Epub Date]|.

96. Zareba G. Idursulfase in Hunter syndrome treatment. Drugs Today (Barc) 2007;43(11):759-67 doi: 10.1358/dot.2007.43.11.1157619[published Online First: Epub Date]|.

97. Product Information: CEREZYME(R) injection, imiglucerase injection. . Secondary Product Information: CEREZYME(R) injection, imiglucerase injection.

 http://www.cerezyme.com/~/media/Files/CerezymeUS/pdf/CZ%20Billing%20Guide%202011%20v1.pdf.

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