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Different dosages are suggested; generally start at low dose 1-2 mg/kg/day increasing by 1-2 mg/kg/day every few days or weeks up to maintenance dose of 10 - 12 mg/kg/day. Dosage can be monitored by measuring CSF levels of neurotransmitter metabolites or verifying normalization of serum prolactin levels(8, 63, 87, 109, 110).

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Nausea (5.5% to 5.7%)

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8. Centre for Evidence-Based Medicine. Secondary Centre for Evidence-Based Medicine  2009. http://www.cebm.net/index.aspx?o=1025.

63. Chien YH, Hsu CC, Huang A, et al. Poor outcome for neonatal-type nonketotic hyperglycinemia treated with high-dose sodium benzoate and dextromethorphan. J Child Neurol 2004;19(1):39-42

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110. Consensus statement from a conference for the management of patients with urea cycle disorders. J Pediatr 2001;138(1 Suppl):S1-5