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Alpha-lipoic acid

Inborn errors of pyruvate dehydrogenase complex

25-50mg/kg/day, dose adjusted according to biochemical and clinical response.(18, 19)

50 mg. 100 mg, and 250 mg capsules

100 mg, 200 mg, and 300 mg tablets

Oral liquid

PO

Muscle cramps, paresthesia and neuropathy symptoms may worsen at first, platelet disorders, purpura, shortness of breath, tension headache, urticaria, eczema

4

18. Kishnani PS, Corzo D, Nicolino M, et al. Recombinant human acid [alpha]-glucosidase: major clinical benefits in infantile-onset Pompe disease. Neurology 2007;68(2):99-109 doi: 10.1212/01.wnl.0000251268.41188.04[published Online First: Epub Date]|.

19. van der Ploeg AT, Clemens PR, Corzo D, et al. A randomized study of alglucosidase alfa in late-onset Pompe's disease. N Engl J Med 2010;362(15):1396-406 doi: 10.1056/NEJMoa0909859[published Online First: Epub Date]|.

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