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Sebelipase alfa (KANUMA)
Wolman disease or lysosomal acid lipase (LAL) deficiency.
For Infants (under 6 months of age at time of diagnosis) with rapidly progressive LAL-D, the recommended starting dosage is 1 mg/kg administered once weekly as an intravenous infusion. For patients who do not achieve an optimal clinical response, consider increasing dosing to 3 mg/kg once weekly.
10-mL, single-use vials.
Has to be diluted with sodium chloride 9 mg/ml (0.9%) solution for infusion using aseptic technique.
IV
Hypersensitivity reactions, fever, chills, fatigue, nausea, vomiting, red swollen skin, headache, tachycardia.
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