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THAM TROMETHAMINE

Refractory severe metabolic acidosis with hypernatremia.

IV dose based on buffer base deficit of extracellular fluid: THAM(R) (mL of 0.3 molar solution) = weight (kg) X base deficit (mEq/L) X 1.1.(168, 169).

THAM acetate solution 

PO

Hypervolemia, Hypoglycemia, respiratory depression.

2b

168. Sapropterin (Kuvan) for phenylketonuria. Med Lett Drugs Ther 2008;50(1287):43-4

169. Schuler A, Blau N, Ponzone A. Monoamine oxidase inhibitors in tetrahydrobiopterin deficiency. Eur J Pediatr 1995;154(12):997

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