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Velaglucerase alfa
Gaucher disease
Adjust based upon disease activity.
IV
Gastrointestinal: Abdominal pain (15% to 18.5%), Nausea (5.6% to 10%).
Hematologic: Partial thromboplastin time increased (11.1%).
Musculoskeletal: Arthralgia (7.5% to 14.8%), Backache (16.7% to 17.5%).
Neurologic: Dizziness (7.5% to 22.2%), Headache (30% to 35.2%).
Respiratory: Upper respiratory infection (30 to 31.5%).
Other: Asthenia (12.5% to 13%), Complication of infusion (22.5% to 51.9%), Fatigue (12.5% to 13%), Fever (12.5% to 22.2%).
1b
181. Roe CR, Sweetman L, Roe DS, David F, Brunengraber H. Treatment of cardiomyopathy and rhabdomyolysis in long-chain fat oxidation disorders using an anaplerotic odd-chain triglyceride. J Clin Invest 2002;110(2):259-69 doi: 10.1172/JCI15311[published Online First: Epub Date]|.