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Zinc
AE: No consensus regarding the dosage but generally the recommended initial dose is 5-10mg/kg/day and maintenance doses of 1-2gram/kg/day (185-188).
Wilson disease: The adult dose is 50 mg t.i.d., each dose separated from food and beverages other than water by at least 1 h. The paediatric dose is 25 mg b.i.d. until 5 years of age, 25 mg t.i.d. until 16 years of age, or until 125 lbs body weight, and then 50 mg t.i.d. (189).
15 mg/ 10mL suspension (extemporaneous preparation)
PO
Nausea, vomiting
4
185. Changela A, Javaiya H, Changela K, Davanos E, Rickenbach K. Acrodermatitis Enteropathica During Adequate Enteral Nutrition. JPEN Journal of parenteral and enteral nutrition. 2011; doi: 10.1177/0148607111407639 [published Online First: 2011/11/01].
186. Mancini AJ, Tunnessen WW, Jr. Picture of the month. Acrodermatitis enteropathica-like rash in a breast-fed, full-term infant with zinc deficiency. Archives of pediatrics & adolescent medicine. 1998;152:1239-40 Online First: 1998/12/18].
187. Weismann K, Hoe S, Knudsen L, Sorensen SS. 65Zinc absorption in patients suffering from acrodermatitis enteropathica and in normal adults assessed by whole-body counting technique. The British journal of dermatology. 1979;101:573-9 Online First: 1979/11/01].
188. Perafan-Riveros C, Franca LF, Alves AC, Sanches JA, Jr. Acrodermatitis enteropathica: case report and review of the literature. Pediatric dermatology. 2002;19:426-31 Online First: 2002/10/18].
189. Brewer GJ, Dick RD, Johnson VD, Fink JK, Kluin KJ, Daniels S. Treatment of Wilson's disease with zinc XVI: treatment during the pediatric years. The Journal of laboratory and clinical medicine. 2001;137:191-8 doi: 10.1067/mlc.2001.113037 [published Online First: 2001/03/10].
